Levothyroxine Sodium T4 Weight Loss Anabolic Steroids CAS 25416-65-3 EINECS 200-221-4
Basic info:
Sodium levothyroxine
CAS: 25416-65-3
MF: C15H10I4NNaO4
MW: 798.85
EINECS: 200-221-4
Product Categories: Hormone Drugs
Appearance: White crystals ,crystalline powder
Assay: 99%
Specific Rotation: -0.10 o --- +0.10 o
Residue on ignition: 0.10% max
Water-insoluble substance: 0.1% max
Fumaric Acid: 1.0% max
Maleic Acid: 0.05% max
Heavy metals(as Pb): 10 ppm max
Arsenic(As) : 4 ppm max
Product Description:
Levothyroxine (INN, USAN) or L-thyroxine is a synthetic thyroid hormone that is chemically identical to thyroxine (T4), which is naturally secreted by the follicular cells of the thyroid gland. It is used to treat thyroid hormone deficiency, and occasionally to prevent the recurrence of thyroid cancer. Like its naturally secreted counterpart, levothyroxine is a chiral compound in the L-form. The related drug dextrothyroxine (D-thyroxine) was used in the past as a treatment for hypercholesterolemia (elevated
cholesterol levels) but was withdrawn due to cardiac side effects. It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.
Levothyroxine (INN, USAN) or L-thyroxine is a synthetic thyroid hormone that is chemically identical to thyroxine (T4), which is naturally secreted by the follicular cells of the thyroid gland. It is used to treat thyroid hormone deficiency, and occasionally to prevent the recurrence of thyroid cancer. Like its naturally secreted counterpart, levothyroxine is a chiral compound in the L-form. The related drug dextrothyroxine (D-thyroxine) was used in the past as a treatment for hypercholesterolemia (elevated
cholesterol levels) but was withdrawn due to cardiac side effects.
Levothyroxine is typically used to treat hypothyroidism, and is the treatment of choice for patients with hypothyroidism, who often require lifelong thyroid hormone therapy. It may also be used to treat goiter via its ability to lower thyroid-stimulating hormone (TSH), a hormone that is considered goiter-inducing. Levothyroxine is also used as interventional therapy in patients with nodular thyroid disease or thyroid cancer to suppress thyroid-stimulating hormone (TSH) secretion.
Applications :
Levothyroxine is typically used to treat hypothyroidism,and is the treatment of choice for patients with hypothyroidism, who often require lifelong thyroid hormone therapy.It may also be used to treat goiter via its ability to lower thyroid-stimulating hormone (TSH), a hormone that is considered goiter-inducing.Levothyroxine is also used as interventional therapy in patients with nodular thyroid disease or thyroid cancer to suppress thyroid-stimulating hormone (TSH) secretion.
Usage:
One of the thyroid hormones involved in the maintenance of metabolic homeostasis. Synthesized and stored as amino acid residues of thyroglobulin, the major protein component of the thyroid follicular colloid. Synthesis and secretion are regulated by the pituitary hormone (TSH).
Levothyroxine is a synthetic (man-made) version of the principle thyroid hormone, thyroxine (T4) that is made and released by the thyroid gland. Thyroid hormone increases the metabolic rate of cells of all tissues in the body. In the fetus and newborn, thyroid hormone is important for the growth and development of all tissues including bones and the brain. In adults, thyroid hormone helps to maintain brain function, food metabolism, and body temperature, among other effects.
Liothyronine Sodium is a synthetic variant of the human body's own thyroid hormone. Indicated as a sympathicolytic and mydriatic. It may have activity as an aphrodisiac. It is suitable for various causes of hypothyroidism.
COA:
| Item |
Specification |
Result |
| Appearance |
An odorless, almost white or buff colored powder |
pass |
| Solubility |
1,Very slightly soluble in water |
pass |
| 2,slightly soluble in alcohol |
pass |
| 3,practically insoluble in most other organic solvents |
pass |
| 4,disolves in diluted aqueous sodium hydroxide solutions |
Pass |
| Identification |
a) Heat about 50 mg with a few drops of sulfuric acid in a porcelain crucible: violet vapors of iodine are evolved. |
pass |
| b)The retention time of the major peak is confirm to the RS |
pass |
| Loss on Drying |
Not more than 4.0% |
0.46% |
[a]20/D
C=1 in 1M HCl/EtOH 1:4 |
+18 ~ +22o |
+20.9o |
| Assay(HPLC) |
Not less than 95.0% |
99.70% |
| Levothyroxine sodium |
Not more than 5.0% |
0.68% |
| Conclusion: |
Up to the Standard for Export |
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