USP Grade SARM Steroids Pirfenidone CAS 53179-13-8 Anti Fibrosis Piresupa
Basic Info:
CAS: 53179-13-8
MF: C12H11NO
MW: 185.22
Appearance: A little yellow to white powder
Purity: 99.70%
Shelf life: 3 years
Standard: Enterprise standard
Usage: Pirfenidone has demonstrated activity in multiple fibrotic conditions, including those of the lung, kidney and liver.
Product Description:
In vitro, pirfenidone can inhibit the uterine flesh tumour cells and leiomyoma cells proliferation. Pirfenidone can inhibit the TGF - beta - 1 inducing fibroblast collagen formation. Inhibition of PDGF, FGF and TGF - beta - 1 inducing fibroblast proliferation. In hamster model, pirfenidone, taken by mouth, that can the prevention and treatment of pulmonary fibrosis induced by bleomycin. Pirfenidone can prevent the sclerosing peritonitis in rats induced by chemical, can also be keloid grafting for the treatment of nude mice. Pirfenidone 0.01 1 mg/ml can suppress the matrix and dose dependent manner serum stimulate uterine fibroids and leiomyoma cell DNA synthesis, the compound has no cytotoxic effect, has no effect on collagen mRNA level also. Pirfenidone in hamster pulmonary fibrosis model can reduce the disease before the collagen I mRNA level enhancement, reduce the level of the lung hydroxyproline and malondialadehyde and lung preserved ammonia acyl hydroxylase activity.
Application:
Pirfenidone has demonstrated activity in multiple fibrotic conditions, including those of the lung, kidney and liver.Biological Activity Antifibrotic agent, effective in models of pulmonary and lung fibrosis. Inhibits collagen production and fibroblast proliferation. Regulates cytokine levels following oral administration in vivo . Potent scavenger of free radicals and inhibitor of lipid peroxidation.
COA:
| Item |
Standard |
Appearance |
White crystal powder |
Melting Point |
102--109째C |
Loss on drying |
<1.0% |
Known single impurity |
<1.0% |
Unknown single impurity |
<0.5% |
Total impurity |
<2.0% |
Assay(as dried) |
99% |
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