Pharmaceutical Intermediates Female Steroids Estriol Hormones Estrogen Receptor CAS 50-27-1
1 . Basic View
| Product Name |
Estriol |
| Synonyms |
TRIDESTRIN |
| CAS |
50-27-1 |
| MF |
C18H24O3 |
| MW |
288.38 |
| EINECS |
200-022-2 |
| mp |
280-282°C(lit.) |
| refractive index |
58 ° (C=0.4, Dioxane) |
| storage temp |
-20°C Freezer |
| appearance |
white powder |
| Manufacturer |
Kafen |
2 . Detailed Description
Estriol can be a weak or strong estrogen depending on if it is given acutely or chronically when given to immature animals, but is an antagonist when given in combination with estradiol.
Estriol may play a role in the development of breast cancer, but based on in vitro research, does appear to act as an antagonist to the G-protein coupled estrogen receptor. Though estriol is used as part of the primarily North American phenomenon of bioidentical hormone replacement therapy.
3 . Application
- Estriol can be measured in maternal blood or urine and can be used as a marker of fetal health and wellbeing. is produced by the adrenal cortex of the fetus. This is converted to estriol by the placenta.
- If levels of unconjugated estriol (uE3 or free estriol) are abnormally low in a pregnant woman, this may indicate chromosomal or congenital anomalies like Down syndrome or Edward's syndrome. It is included as part of the triple test & quadruple test for antenatal screening for fetal anomalies.
- Because many pathological conditions in a pregnant woman can cause deviations in estriol levels, these screenings are often seen as less definitive of fetal-placental health than non-stress testing. Conditions which can create false positives and false negatives in estriol testing for fetal distress include preeclampsia, anemia, and impaired kidney function.
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