Melanotan 1 Muscle Building Peptides For Fat Decomposition CAS 75921-69-6
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Melanotan-I is a synthetic hormone that is stimulating the release of melanocyte-hormone in animal cells. These melanocyte-hormones are the ones responsible for the pigmentation of the skin due to their interaction with melanocortin-1 receptors in the epidermis. These hormones are being released from the pars intermedia of the pituitary glands in some of the eukaryotic animal species. However, these are also prominent in the keratinocytes and the melanocytes of the human skin.
It was attempted to be extracted from biological matrices such as cell culture transport media and human plasma. This was done by relatively fast and isocratically within 8.0 minutes using the C8 reversed column. In order to successfully isolate the said protein, the mobile phase has been optimized using 0.1 molar of phosphate buffer with 18 μl/l triethylamine at pH 2.50 with an average flow rate of 1 iml/min and being detected at 214 nm. This study have shown that results are very consistent and has already been used in investigating the transport of melanotan-I in the caco-2 cell monolayer model . Studies have shown that in organisms that do not possess fur or thick hair, the superpotent derivative of the menocyte stimulating hormone which is the melanotan-1 have induced tanning.
Furthermore, it has already been demonstrated that malenotan-1 also induces eumelanin synthesis in the skin of animals, especially humans which is coincidental with its tanning effect. When combined with UV-B light or sunlight, a tanning synergy between these factors was strongly observed. Furthermore, it was shown that when melanotan-1 was combined with sunlight, it produced a long-lasting tan at the sun-exposed back sites. However, when induced in greater amounts, melanotan-1 has been shown to induce side-effects. In the same study conducted by Dorr et al. , nausea was observed in the experimental units. Possible explanation for this is the interaction of the melanotan-1 with the melanocortin-3 receptors which in turn are found in the gastrointestinal tissues of animals.
Melanotan 1 is an analogue of MSH, which is manufactured within the pituitary gland. It is classified as a melanocortin, and, like all melanocortins, it acts on certain physical systems which influence hair color, skin pigment, sexual arousal, sexual desire and appetite.
The more melanin the body produces, the darker the skin gets. This peptide will allow for self-tanning without UV exposure. This means that the body will grow tanned all over, even in places which aren't exposed to sunlight. However, UV exposure will accelerate the tanning process in exposed areas. The role that UV exposure plays sometimes results in a tan which may not be perfectly even all over.
Most users find that they are most tanned on their faces, arms and stomachs. The genitals may also take on a tanned appearance during therapy with this peptide.
The initial creation of the Melanotan 1 peptide tanning analogue can be credited to the University of Arizona.
During the course of study aimed at developing a defense against skin cancer, focus was placed on developing a method of stimulating naturl melanogenesis, or the natural production of melanin in the skin, without direct exposure to the potentially harmful ultraviolet radiation in sunlight. Initially, University of Arizona researchers attempted to directly administer the naturally occurring hormone alpha-MSH in order to elicit this desired result. Although this strategy exhibited promising results, it was determined that the naturally occurring MSH had a prohibitively short half-life to be of realistic use as a therapeutic remedy. However, the positive results gleaned from MSH administration encouraged further research into the development of Melanotan 1, which exhibits similar effects whilst possessing an extended half-life for functional therapeutic utilization. The researchers, headed by Victor J. Hruby and Mac E. Hadley, found a peptide, [Nle4, D-Phe7]-α-MSH, that was approximately 1,000 times more potent than natural α-MSH. They named this new peptide molecule "Melanotan" (later Melanotan-1).
Melanotan 1 (also referred to as Afamelanotide) is a synthetic peptide variant of a peptide hormone, called alpha-Melanocyte stimulating hormone or MSH that is naturally produced in the body and is responsible for stimulating melanogenesis, a peptide process for pigmentation of the skin. Alpha-MSH activates certain melanocortin receptors in the process of exerting its effects. Indeed, MSH also exerts potent influence over lipid metabolism, appetite, and sexual libido via these melanocortin receptors. As a result, Melanotan-1 sunless skin tanning effects. While Melanotan 2 and PT-141 have been studied at length as a potential remedies for the treatment of sexual dysfunction, Melanotan-1 has been researched extensively for use in protecting against the harmful effects of ultraviolet radiation from sunlight due to its melanogenesis-stimulating properties.
Both Melanotan-1 and Melanotan 2 are analogs of the peptide hormone alpha-melanocyte stimulating hormone (α -MSH) that tend to induce skin tanning. Unlike Melanotan 1, Melanotan 2 has been shown to have aphrodisiac properties, the additional effect of increasing libido. Melanotan-1 is a non selective agonist of the melanocortin receptors (MC1R, MC3-5R). As an analogue of α -MSH, its mechanism of action is biomimicry of the natural mammalian tanning process.
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