Shanghai Doublewin Bio-Tech Co., Ltd.
|Place of Origin:||China|
|Minimum Order Quantity:||10g|
|Packaging Details:||According to your requirements.|
|Delivery Time:||Within 24 hours after receiving your payment.|
|Payment Terms:||Western Union,Money Gram,Bank Transfer,Bitcoin|
|Product Name:||Chlormadinone Acetate||CAS:||302-22-7|
|Assay:||99%||Appearance:||White Or White Crystalline Powder|
estrogen blocker steroids,
Product Name: Chlormadinone acetate
storage temp: -20°C Freezer
Appearance: White Or White Crystalline Powder
Chlormadinone acetate (CMA) is a derivative of progesterone (17-acetoxy-6-chloro-4,6-pregnadiene-3,20-dione), first synthesized in 1961 and is used as an orally effective progestogen in hormone replacement therapy (HRT), and in combination with ethinyl estradiol (EE) in contraception since 1999. Chlormadinone acetate has a strong progestogenic effect about one-third higher than that of progesterone and may vary depending on the previous effect of an estrogen, i.e., estrogens may promote the formation of progesterone receptors and proliferation of the endometrium. Like progesterone, it is anti-estrogenic and has no partial androgenic effect (at the doses used for contraception and HRT). In contrast to progesterone, it has a slight glucocorticoid effect, a pronounced anti-androgenic effect and no anti-mineralocorticoid effect. No pregnancy-maintaining effect of CMA has been demonstrated in humans.
The anti-androgenic effect of CMA is presumed to be the result of both its binding to androgen receptors competitively inhibiting the effect of endogenous testosterone and dihydrotestosterone and the competitive inhibition of 5-reductase. In this respect, dosing of CMA is crucial; agonistic effects are observed when doses are increased from those optimal for an antagonistic effect.
Chlormadinone acetate has a strong anti-gonadotropic effect, through negative feedback on gonadotropin secretion, and has been used for more than 20 years alone for contraception in arterial risk patients. The clinical and metabolic tolerability of CMA has been demonstrated in numerous clinical studies with duration of treatment of up to 2.5 years.
The more recent application of CMA as an oral contraceptive in combination with EE (Neo Eunomin, Belara) has proven highly successful, with studies reporting excellent contraceptive efficacy, high tolerability and adherence due to a good side effect profile and positive effects on preexisting dysmenorrhea, skin and hair conditions.
Chlormadinone acetate (CMA) is a derivative of naturally secreted progesterone that shows high affinity and activity at the progesterone receptor. It has an anti-estrogenic effect and, in contrast to natural progesterone, shows moderate anti-androgenic properties. CMA acts by blocking androgen receptors in target organs and by reducing the activity of skin 5alpha-reductase. It suppresses gonadotropin secretion and thereby reduces ovarian and adrenal androgen production. CMA shows high contraceptive efficacy by inhibiting ovulation due to its ability to suppress or disrupt endogenous gonadotropin secretion and, by this, inhibits follicular growth and maturation. In addition, it suppresses endometrial thickness and increases the viscosity of cervical mucus.
|Product name||CAS NO.||Product name||CAS NO.|
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|Chloramphenicol||56-75-7/ 2787-09-9||Doxorubicin hydrochloride||25316-40-9|
|Omeprazole||73590-58-6/ 119141-89-8||Benzyl benzoate||120-51-4|
|Amikacin disulfate salt||39831-55-5/ 149022-22-0||Nitazoxanide||55981-09-4|
|Dexamethasone sodium phosphate||55203-24-2/ 312-93-6||Secnidazole||3366-95-8|
|Lincomycin hydrochloride||7179-49-9||Chlorhexidine Gluconate||18472-51-0|
|1,3-Dimethylbutylamine hydrochloride||71776-70-7||4 amino-2-Methylpentane citrate(AMP Citrate)||71776-70-0|
|We also Supply|
|Oral Products||Oxandrolone (Anavar)||Stanozolol (Winstrol)|
|Testosterone||Test Base||17-methyltestostero(methyl testos terone)|
|Test Enanthate||17α-Methyl-Testos terone|
|Test Acetate||Oral turinabol(4-Chlorodehydromethyltestosterone)|
|Test Propionate||Turinabol(Chloroterone Acetate,Clostebol Acetate)|
|Test Undecanoate||Test Cypionate|
|1-Testosterone||Test Sustanon 250|
|Nandrolone Propionate||Nandrolone Cypiontate|
|Nandrolone Decanoate(DECA)||Stanolone (DHT)|
|Trenbolone acetate (Finaplix)|
|Trenbolone enanthate (Parabolan)|
|Trenbolone hexahydrobenzyl Carbonate|
|Methenolone||Drostanolone Propionate (Masteron p)|
|Methenolone Enanthate||Methenolone Acetate|
|Others||Methyl dienedione||2, 4-Dinitrophenol|
|Sex Enhancer||Flibanserin||Acetildenafil (Hongdenafil)|
|Cia lis (Tadalafil)||Yohimbine Hcl|
|Via gra (Silde nafil) Vardenafil (Le vitra)|
|Pain Killer||Benzocaine / Benzocaine hcl||Tetracaine / Tetracaine HCL|
|Procaine / Procaine Hcl||Bupivacaine/ Bupivacaine HCL|
|Lidocaine HCL||Articaine / Articaine hcl|
|Anti-Estrogen||Tamoxifen Citrate (Nolvadex)||Anastrozole (Arimidex)|
|Clomiphene citrate (Clomid)||Letrazole(Femara / For mestane)|
|Pharmaceuticals||Phe nacetin||Raloxifene HCL|
|Dexamethasone Sodium Phosphate||Fura zabol THP|
|Safe Organic Solvents||Gamma-Butyrolactones(GBLsolvents )||Benzyl Alcohol(BA)|
|Grape Seed Oil(GSO)||Poly Ethylene Glycol(PEG)|
|H G H&Peptides||HGH 176-191 2mg/vial||Ipamorelin 2mg/vial|
|MGF PEG MGF||Hexarelin 2mg/vial|
|CJC-1295 / with DAC||Sermorelin 2mg/vial|
|PT-141 10mg/vial||Selank 5mg/vial|
|MT-1 MT-2 10mg/vial||Follistatin 344|
|GHRP-2 5mg/vial & 10mg/vial||Follistatin 315|
|GHRP-6 5mg/vial & 10mg/vial||Eptifibatide|
|Andarine / S4||RAD-140|
|Andarine / GTX-007||SR9011|
1: After our quation ,you will choose to accept or not.
2: If you decide to have a try, choose a payment method to pay for the order.
3: We will sent the package out in 24hours after we received the payment ,then will sent the tracking number with packaging detail to you via mai.
4: We will help track the package until you receive it successful,if accident happen ,we will see the reason to decide re-sent for free or half-price re-sent.
Our Competitive Advantages:
1. Rich experience: we specialize in this field for many years, our steroids have been exported almost over the world. Such as USA, Canada, UK, Brazil, Germany, Russia, Australia, Greece, Poland, Bulgaria, Rumania, Netherlands, Sweden, Ukraine, Latvia, Lithuania, Ireland, Austria, Iran, Turkey, Mexico, Thailand, India, Malaysia, Singapore, other Middle East countries, European countries, American countries and more Areas.
2. Great quality: High purity and Favorable price. Good quality is the first base of our success. All of our products enjoys high purity. Thus, it can make sure your demand. Welcome order the samples, MOQ just 10 grams.
3. Safe and fast delivery: Lots of different discreet safe packing methods, experience in choosing express, 4~7 days to arrive, successful rate 99%.
4. Experiential order and cooperation: Besides raw powders, we offer hormone solution and Recipes. We can teach you or discuss how to make hormone solution on the site. Any discussion and question is welcome!
Packaging & Service:
1. Mass stock, to make sure delivery promptly every day when the payment is done.
2. Having been engaged in this field for years, we have sophisticated and professional logistics department, which can guarantee safe and speedy delivery.
3. Well-trained and disciplined packing team which is professional enough to provide you a safe package. It also avoid a lot of emergency happen during the delivery so that high customs pass is guaranteed. Unique ways to ship 10grams to 20 kilograms powders(or 100ml to 30 Liter liquids) at one time to your destination.
4. Packing pictures and tacking number are provided within 24 hours as soon as receiving the payment. Updated tracking code will be provided every other day just for you can hold a palm of your package.
5. Perfect after-sale service: Any questions or problems happened after receiving the product.
Please feel free to contact us. 24/7 online to solve your various problems!
Contact Person: Eunice
Tel: +86 17683962426