Basic Info.
Product Name: Progesterone
Synonyms: progestin;PRIMOLUT
CAS: 57-83-0
MF: C21H30O2
MW: 314.46
EINECS: 200-350-6
mp: 128-132°C(lit.)
alpha: 186°(c=1, ethanol)
refractive index: 182 ° (C=2, Dioxane)
storage temp: Store at RT
solubility H2O: 25 mg/mL, may be clear to slightly hazy
Appearance: white powder
Water Solubility: <0.1 g/100 mL at 19°C
Stability: Stable. Incompatible with strong oxidizing agents.
Description:
Progesterone is a female Progesterone Hormones important for the regulation of ovulation and menstruation.
Women take progesterone by mouth for inducing menstrual periods who have not yet reached menopause but are not having periods due to a lack of progesterone in the body; And treating abnormal uterine bleeding associated with hormonal imbalance, and severe symptoms of premenstrual syndrome (PMS). Progesterone is also used to prevent overgrowth in the lining of the uterus in postmenopausal women who are receiving estrogen hormone replacement therapy. Progesterone is also used in combination with the hormone estrogen to "oppose estrogen" as part of hormone replacement therapy. If estrogen is given without progesterone, estrogen increases the risk of uterine cancer.
One of progesterone's most important functions is to cause the endometrium to secrete special proteins during the second half of the menstrual cycle, preparing it to receive and nourish an implanted fertilized egg. If implantation does not occur, estrogen and progesterone levels drop, the endometrium breaks down and menstruation occurs.
If a pregnancy occurs, progesterone is produced in the placenta, and levels remain elevated throughout the pregnancy. The combination of high estrogen and progesterone levels suppress further ovulation during pregnancy. Progesterone also encourages the growth of milk-producing glands in the breast during pregnancy.
High progesterone levels are believed to be partly responsible for symptoms of premenstrual syndrome (PMS), such as breast tenderness, feeling bloated and mood swings. When you skip a period, it could be because of failure to ovulate and subsequent low progesterone levels.
Applications:
Progesterone is a female Progesterone Hormones important for the regulation of ovulation and menstruation.
Women take progesterone by mouth for inducing menstrual periods who have not yet reached menopause but are not having periods due to a lack of progesterone in the body; And treating abnormal uterine bleeding associated with hormonal imbalance, and severe symptoms of premenstrual syndrome (PMS). Progesterone is also used to prevent overgrowth in the lining of the uterus in postmenopausal women who are receiving estrogen hormone replacement therapy. Progesterone is also used in combination with the hormone estrogen to "oppose estrogen" as part of hormone replacement therapy. If estrogen is given without progesterone, estrogen increases the risk of uterine cancer.
COA:
| Product |
PROGESTERONE(MICRONIZED) |
| CAS No |
57-83-0 |
Packing |
1kg/bag |
| Date of manufacturing |
13th, Jan, 2015 |
Shelf life |
12th, Jan, 2019 |
| Standard |
USP37 |
| Items |
Specification |
Results |
| Characteristics |
White power |
Conforms |
| Identification |
A:IR B:UVyiban |
Conforms |
| Melting range |
126-131ºC |
126.9-130.8ºC |
| Specific optical rotation |
+175-183° |
181.09° |
| Loss on drying |
≤0.5% |
0.25% |
| Methanol |
≤129ppm |
Conforms |
| Ethanol |
≤2500ppm |
Conforms |
| Petroleum ether |
≤108ppm |
Conforms |
| |
≤15ppm |
Conforms |
| Cyclohexanone |
≤33ppm |
Conforms |
| Assay |
97.0-103.0% |
98.69% |
| Microm |
100%≤20μm |
100%≤20μm |
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