Basic Info.
Synonyms: Estradiol, 50-28-2, steroid powder.
CAS No.: 50-28-2
Formula: C18H24O2
Molecular Weight: 272.39
EINECS: 200-023-8
Density: 1.17 g/cm3
Melting Point: 178-179 ° C(lit. )
Boiling Point: 445.917 ° C at 760 mmHg
Flash Point: 209.634 ° C
Purity: 99%
Application: Pharmaceutical Intermediates
Appearance: White crystalline powder
Function and use: It is a kind of estrogen, can promote and regulate the normal development of women's genitals and secondary. Can cause hyperplasia of mammary gland carcinoma development, but in larger doses, can inhibit pituitary prolactin release, and reduce the secretion of milk.
Description:
Estradiol (o) estradiol C18H24O2 being a sex hormone. With alpha, beta, two types of alpha physiological function is strong. Steiner, winter (Wintersteiner et al. 1935) was extracted from the horse urine pregnancy, moreover also can cause from the urine, placenta, pig ovary, etc. There is also a male horse testis or urine. Because it has the very strong sex role, so that it or its ester is, in fact, ovarian secretion of the sex hormones of the most important. Estradiol benzoate is decided to one of the international unit of sex hormone titer standard substance and used.
Function and use: It is a kind of estrogen, can promote and regulate the normal development of women's genitals and secondary. Can cause hyperplasia of mammary gland carcinoma development, but in larger doses, can inhibit pituitary prolactin release, and reduce the secretion of milk. Potent mammalian estrogenic hormone produced by the ovary.
Application:
Both men and women produce estrogen hormones. Estrogens are responsible for female sexual development and function, such as breast development and the menstrual cycle. In women, estrogens are produced mainly in the ovaries and in the placenta during pregnancy. Small amounts are also produced by the adrenal glands. In men, small amounts of estrogens are produced by the adrenal glands and testicles. Small amounts of estrone are made throughout the body in most tissues, especially fat and muscle. This is the major source of estrogen in women who have gone through menopause.
Estradiol acts primarily as a growth hormone for the reproductive structures including the lining of the vagina, the fallopian tubes, the endometrium and the cervical glands. The hormone is also required to maintain oocytes (eggs in the ovary) and triggers a series of events that lead to ovulation. In addition, estradiol works in conjunction with progesterone to prepare the womb lining for implantation. In males, estradiol aids sperm maturation and also helps to maintain a healthy libido.
COA
Product name |
Estradiol |
| Appearance |
White crystalline powder |
| Characteristics |
White or creamy white, crystalline powder |
conform |
| Melting point |
173 ~ 179°C |
178~ 179°C |
| Specific rotation |
+76°~+83° |
+78.5° |
| Water |
≤3.5% |
pass |
| Assay |
97 .0~ 103.0% |
99.07% |
| Loss on drying |
≤0.5% |
0.21% |
| Related substances |
total impurities ≤1.0% |
Pass |
| |
any individual impurity ≤0.5% |
Pass |
| Residual solvents |
ethanol ≤0.5% |
Pass |
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