Guangzhou Kafen Biotech Co.,Ltd
|Place of Origin:||China|
|Minimum Order Quantity:||As your required.|
|Packaging Details:||According to your requirements.|
|Delivery Time:||Within 24 hours after receiving your payment.|
|Payment Terms:||Western Union,Money Gram,Bank Transfer,Bitcoin|
|Product Name:||Epimedium Extract||CAS:||489-32-7|
|Synonyms||Horny goat weed extract ; ICARIINE ; ICARRIN;epimedium extract ; Epimedium herb Ext ; Epimedium P.E ; Epimedium Brevicornum P.E ; Epimedim Brevicormum P.E|
|Chemical Properties||Light yellow to yellow solid|
|Usage||Male Sexual Enhancement|
Sex Steroid HormonesIcariin is a chemical compound classified as a flavonol glycoside , a type of flavonoid . It is the 8-prenyl derivative of kaempferol 3,7-O-diglucoside . The compound has been isolated from several species of plants belonging to the genus Epimedium which are commonly known as Horny Goat Weed or Yin Yang Huo . Extracts from these plants are reputed to produce aphrodisiac effects , and are used in traditional Chinese medicine to enhance erectile function .
Sex Steroid Hormones , It is thought that icariin is an active component of Epimedium extracts , as it has been shown to share several mechanisms of action with compounds used in Western medicine to treat impotence . In particular , icariin is a weak PDE5 inhibitor in vitro and enhances the production of nitric oxide , as well as mimicking the effects of testosterone in rats . It is a weak antioxidant and has antidepressant-like effects in mice . It also has neuroprotective effects in rats.
|Exterior||Light yellow to yellow solid||conform|
|Degree of fineness||100 mesh||conform|
|Loss on drying||<5%||3.5%|
|Residue on ignition||<2.5%||2.1%|
|Storage conditions||Top dry and low temperature sealing||Top dry and low temperature sealing|
To effectively treat bone diseases using bone regenerative medicine , there is an urgent need to develop safe cheap drugs that can potently induce bone formation . Here , we demonstrate the osteogenic effect of icariin , the main active compound of Epimedium pubescens . Icariin induced osteogenic differentiation in pre-osteoblastic MC3T3-E1 cells and mouse primary osteoblasts . Icariin upregulated the mRNA expression levels of the osteoblast marker genes runt-related transcription factor 2 (Runx2) and inhibitor of DNA-binding 1 (Id-1) . The osteogenic effect was inhibited by the introduction of Smad6 or dominant-negative Runx2 , as well as Noggin treatment . Furthermore , icariin induced the mRNA expression of bone morphogenetic protein (BMP)-4 . These data suggest that icariin exerts its potent osteogenic effect through induction of Runx2 expression , production of BMP-4 and activation of BMP signaling . The extremely low cost of icariin and its high abundance make it appealing for bone regenerative medicine .
1) Rich experience
Our company is a professional raw powder factory in China for over 10 years, all powders are factory directly supplying.
2) Wide range of export
Our products have exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Australia, Japan, Korea and many other countries, over 100kgs each month.
3) High customs pass guaranteed.
Professional team special for package and shipment and staring on tracking code 24hours for customs pass guaranteed. 100% pass to UK, Norway, Poland, Spain, USA, Canada, Brazil; 98% pass to Germany, Russia, Australia, New Zealand.
4) Fast leading time
Most of powders are in stock, Chargeable samples are available, Could be shipped out within 24hours.
5) High quality, good price, fast and safety delivery.
Shipment by DHL, , FEDEX, HKEMS, EMS, etc