Basic Info:
Product name: Hydrochloride
CAS No: 119356-77-3
MF: C21H23NOHCl
MW: 341.88
MS:
Purity: 98%
Appearance: White powder, odorless, slightly sweet, soluble in water and alcohol.
Product Description:
hydrochloride is an oral drug for the treatment of ED, used in the treatment of erectile dysfunction and premature ejaculation, erectile function impairment and premature ejaculation has very significant improvements. There are over 1500 documents to prove the caused by different causes impotence premature ejaculation, knew the success rate is above 80%, and show its reliable curative effect, through the use of more than 20 million people worldwide, proved its long-term stability, the safety of 25 to 60 minutes of work function to coincide with a time needed for foreplay, knew the time adjustment in the highest drug concentration time, help both husband and wife a satisfactory sex life.
Initially, hydrochloride is given as a 30 mg tablet one to three hours before sexual intercourse. The dose may be increased by the prescribing doctor to 60 mg, depending on response and tolerance.
Application:
Treat male premature ejaculation and erectile dysfunction., marketed as (among and other brands) is the first compound developed specially for the treatment of premature ejaculation (PE) for men at th age of 18–64 years old. works by inhibiting the serotonin transporter, increasing serotonin’s action at the post synaptic cleft, so as to delay ejaculation.. As a member of selective serotonin reuptake inhibitor (SSRI) family, was initially created as an antidepressant. However, unlike other SSRIs, is absorbed and eliminated rapidly in the body. Its fast response makes it suitable for the treatment of PE but not as an antidepressant.
Due to the lack of specific approval treatment for PE in the US and some other countries, other SSRIs such as Fluoxetine, Paroxetine, Sertraline, Fluvoxamine, and Citalopram have been used as clinical drugs to treat PE. Waldinger’s meta analysis shows that the use of these conventional antidepressants increases IELT from two to nine times above base line in comparison of three to eight times when is used. However, these SSRIs must be taken daily in order to achieve meaningful efficacy, and the long half-life increases the risk of the drug accumulation and as a consequence an increased adverse effects such as decreasing sexual libido and causing erectile dysfunction. , on the other hand, is a fast-acting SSRI. It is rapidly absorbed and eliminated from the body within a few hours. This favorable pharmacokinetics minimizes the risk of the drug’s accumulation in the body, and therefore reducing side effects.
COA:
| ITEMS |
STANDARD |
RESULTS |
| Characteristics |
White or almost white crystalline powder |
White crystalline powder |
| Melting point |
175.0~177.0℃ |
174.0~179.0℃ |
| Specific rotatlon |
+128°±3(C=1,CH3OH) |
+128°±3(C=1,CH3OH) |
| Loss on drying |
≤0.5% |
0.32% |
| Heavy metals |
0ppm |
0ppm |
| Relative substance |
≤0.1%
Total impurity
|
0.07% |
| Assay(on drled basis) |
≥99.5% |
99.61% |
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