1.Basic info.
Product Name: (GHK)2-Cu(Copper Peptide) Sequence
Synonyms: GHK-Cu (Copper peptide) (Gly-His-Lys)2·Cu
CAS: 49557-75-7
Molecular Formula: C28H46N12O8Cu
Molecular Weight: 742.29
2.Product Description:
Blue copper peptides may be without hurt the skin, does not irritate the skin, increase the vitality of cells, the body gradually repair the loss of collagen, subcutaneous tissue strong, rapid wound healing, and thus achieve wrinkle anti-aging purposes. GHK-Cu composition is: glycine - histidine - lysine - copper (glycyl-L-histidyl-L-lysine -copper), copper ion Cu2 + is not the yellow metal is copper, but appear blue in aqueous solution Therefore GHK-Cu is also known as blue copper peptides.
Copper peptide GHK-Cu is a naturally occurring copper complex of a glycyl-L-histidyl-L-lysinepeptide. Since it has three amino acids it is called tripeptide. The GHK-Cu tripeptide has strong affinity for copper(II) and was first isolated from human plasma. It can be found also in saliva and urine.
GHK-Cu, Copper Peptide, is a naturally occurring human tri-peptide. In plasma, the level of GHK-Cu is about 200 ng/ml at age 20. By the age of 60, the level drops to 80 ng/ml. Scientific studies conducted in different research laboratories around the world have established that human tri-peptide GHK-Cu possesses a plethora of biological actions including activation of wound healing, attraction of immune cells, antioxidant and anti-inflammatory effects, stimulation of collagen and glycosaminoglycan synthesis in skin fibroblasts and promotion of blood vessels growth. Recent studies indicate its important role in stem cell biology and anti-tumor defense. Since GHK-Cu plays an important role in skin biology, it is widely used in cosmetics as a reparative and anti-aging ingredient. The levels of GHK decrease as you age.
Copper peptide products are used for wound healing (Iamin, BioHeal),skin renewal (Blue Copper, Neova, Neutrogena copper, P&R), and hair growth (Tricomin, Graftcyte).
Copper is an important trace element that has been found to be important in wound healing and enzymatic processes.Lysyloxidase is an important enzyme in collagen and elastin production and it is dependent upon the action of copper.
3.Product Applications:
(1) Chemoattraction of repair cells such as macrophages, mast cells, capillary cells;
(2) Anti-inflammatory actions (suppression of free radicals, thromboxane formation, release of oxidizing iron, transforming growth factor beta-1, tumor necrosis factor alpha and protein glycation while increasing superoxide dismutase, vessel vasodilation, blocking ultraviolet damage to skin keratinocytes and improving fibroblast recovery after X-ray treatments);
(3) Increases protein synthesis of collagen, elastin, metalloproteinases, anti-proteases, vascular endothelial growth factor, fibroblast growth factor 2, nerve growth factor, neutrotropins 3 and 4, and erythropoietin;
(4)Increases the proliferation of fibroblasts and keratinocytes; nerve outgrowth, angiogenesis, and hair follicle size.
GHK-Cu stimulates wound healing in numerous models and in humans. Controlled studies on aged skin demonstrated that it tightens skin, improves elasticity and firmness, reduces fine lines, wrinkles, photodamage and hyperpigmentation. GHK-Cu also improves hair transplant success, protects hepatic tissue from tetrachloromethane poisoning, blocks stomach ulcer development, and heals intestinal ulcers and bone tissue. These results are beginning to define the complex biochemical processes that regulate tissue remodeling.
Copper-Peptides are used clinically for wound healing, increased skin healing after laser resurfacing and chemical peels, and for improving the success of hair transplantation.
4.COA:
| Test Items |
Specification |
Test Results |
| Description |
White or almost white crystalline powder |
White crystalline powder |
| Melting Point |
191.0~193.0ºC |
192ºC |
| Loss of drying |
≤1.0% |
0.5% |
| Heavy Metal |
≤20ppm |
15ppm |
| TLC |
Only one spot |
Only one spot |
| Assay |
≥99.5% |
99.91% |
| Conclusion |
It complies with the USP 32. |
Email:doublewin-eunice@nandrolonesteroid.com
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