1.Basic info.
Product name: Mifepristone
Synonyms: r38486
CAS: 84371-65-3
MF: C29H35NO2
MW: 429.59
mp: 195-198°C
storage temp: 2-8°C
appearance: Pale Yellow Solid
2.Product Description:
Mifepristone is a synthetic steroid compound with both antiprogesterone and antiglucocorticoid properties. The compound is a 19-nor steroid with substitutions at positions C11 and C17 (17 beta-hydroxy-11 beta-[4-dimethylamino phenyl] 17 alpha-[1-propynyl]estra-4, 9-dien-3-one), which antagonizes cortisol action competitively at the receptor level.
Mifepristone is a progesterone receptor antagonist used as an abortifacient in the first months of pregnancy, and in smaller doses as an emergency contraceptive. It is also a powerful glucocorticoid receptor antagonist.
Mifepristone was the first antiprogestin to be developed and it has been evaluated extensively for its use as an abortifacient. The original target for the research group, however, was the discovery and development of compounds with antiglucocorticoid properties. These antiglucocorticoid properties are of great interest in the treatment of severe mood disorders and psychosis, although a review of published articles was inconclusive on their efficacy, and considered the use of these drugs in mood disorders at 'proof of concept' stage. It is on the World Health Organization's List of Essential Medicines.
3.Product Applications:
Mifepristone plays a role on the receptor level of new antifertility drugs, no progesterone, androgen, estrogen activity. It has an effect on softening and dilating uterine neck. It is a new anti - progesterone, and anti-glucocorticoid activity, without progesterone, estrogen, androgen and estrogen activity. And progesterone receptor affinity is 5 times stronger than progesterone. For termination of early pregnancy, reinstating menstruation and terminating pregnancy, fetal death, etc. In induction of labor.
4.COA:
| Ref. Standard |
CP 2010 version |
| Results Of Analysis Tests |
| Test |
Analysis StandardResults |
|
| Description |
Light Yellowish Crystalline Powder |
Light Yellowish Crystalline Powder |
| Identification |
(1)304nm,260nm. |
confirmed |
| Melting Point |
192ºC~196ºC |
192ºC~196ºC |
| Specific Rotation |
+124°~ +129° |
+127.1° |
| (HPLC) Related substances |
(1)(Single):≤0.5% |
0.31% |
| |
(2)(Total):≤1.0% |
0.59% |
| Loss On Drying |
≤0.5% |
0.1% |
| Assay |
≥98.5% |
99.5% |
| Sieve analysis |
≤30¦Ìm |
confirmed |
Conclusion
|
This product conforms to the CP 2010 and enterprise internal control
standards |
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