Pharmaceutical Raw Materials Female Steroids Raw Hormone Powders Mifepristone CAS:84371-65-3
Basic Info.
Mifepristone
CAS Number: 84371-65-3
Molecular Formula: C29H35NO2
Molecular Weight: 429.65
Melting Point: 195-198 Degree C
Appearance: Light yellowish powder
Use: Used for a variety of allergic skin diseases and cosmetic additives
Packing: 1kg/aluminum foil bag
Assay: 99%
Standard: Enterprise Standard
Used: raw material powder
Packing: 1kg/aluminum foil bag
Description:
Mifepristone is a synthetic steroid compound with both antiprogesterone and antiglucocorticoid properties. The compound is a 19-nor steroid with substitutions at positions C11 and C17 (17 beta-hydroxy-11 beta-[4-dimethylamino phenyl] 17 alpha-[1-propynyl]estra-4, 9-dien-3-one), which antagonizes cortisol action competitively at the receptor level.
Mifepristone is a progesterone receptor antagonist used as an abortifacient in the first months of pregnancy, and in smaller doses as an emergency contraceptive. It is also a powerful glucocorticoid receptor antagonist.
Applications:
Mifepristone is used alone or in combination with misoprostol (Cytotec) to end an early pregnancy. Early pregnancy means it has been 49 days or less since your last menstrual period began. Mifepristone is in a class of medications called antiprogestational steroids. It works by blocking the activity of progesterone, a substance your body makes to help continue pregnancy.
Mifepristone is also available as another product (Korlym), which is used to control hyperglycemia (high blood sugar) in people with a certain type of Cushing's Syndrome in which the body makes too much of the hormone cortisol. This monograph only gives information about mifepristone (Mifeprex), which is used alone or in combination with another medication to end an early pregnancy. If you are using mifepristone to control hyperglycemia caused by Cushing's syndrome, read the monograph entitled mifepristone (Korlym) that has been written about this product.
Mifepristone (or RU-486) is a synthetic steroid compound with both antiprogesterone and antiglucocorticoid properties. The compound is a 19-nor steroid with substitutions at positions C11 and C17 (17 beta-hydroxy-11 beta-[4-dimethylamino phenyl] 17 alpha-[1-propynyl]estra-4, 9-dien-3-one), which antagonizes cortisol action competitively at the receptor level.
Mifepristone is a progesterone receptor antagonist used as an abortifacient in the first months of pregnancy, and in smaller doses as an emergency contraceptive. It is also a powerful glucocorticoid receptor antagonist, and has occasionally been used in refractory Cushing's syndrome (due to ectopic/neoplastic ACTH/cortisol secretion).
Mifepristone was the first antiprogestin to be developed and it has been evaluated extensively for its use as an abortifacient.
Mifepristone Specifications:
| Ref. Standard |
CP 2010 version |
| Results Of Analysis Tests |
| Test |
Analysis StandardResults |
|
| Description |
Light Yellowish Crystalline Powder |
Light Yellowish Crystalline Powder |
| Identification |
(1)304nm,260nm. |
confirmed |
| Melting Point |
192ºC~196ºC |
192ºC~196ºC |
| Specific Rotation |
+124°~ +129° |
+127.1° |
| (HPLC) Related substances |
(1)(Single):≤0.5% |
0.31% |
| |
(2)(Total):≤1.0% |
0.59% |
| Loss On Drying |
≤0.5% |
0.1% |
| Assay |
≥98.5% |
99.5% |
| Sieve analysis |
≤30¦Ìm |
confirmed |
Conclusion
|
This product conforms to the CP 2010 and enterprise internal control
standards |
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