Basic Info:
| Product name |
Icariin |
| Synonyms |
Horny goat weed extract ; ICARIINE ; ICARRIN;epimedium extract ; Epimedium herb Ext ; Epimedium P.E ; Epimedium Brevicornum P.E ; Epimedim Brevicormum P.E |
| CAS |
489-32-7 |
| MF |
C33H40O15 |
| MW |
676.66 |
| Chemical Properties |
Light yellow to yellow solid |
| Usage |
Male Sexual Enhancement |
Product Description:
Sex Steroid HormonesIcariin is a chemical compound classified as a flavonol glycoside , a type of flavonoid . It is the 8-prenyl derivative of kaempferol 3,7-O-diglucoside . The compound has been isolated from several species of plants belonging to the genus Epimedium which are commonly known as Horny Goat Weed or Yin Yang Huo . Extracts from these plants are reputed to produce aphrodisiac effects , and are used in traditional Chinese medicine to enhance erectile function .
Sex Steroid Hormones , It is thought that icariin is an active component of Epimedium extracts , as it has been shown to share several mechanisms of action with compounds used in Western medicine to treat impotence . In particular , icariin is a weak PDE5 inhibitor in vitro and enhances the production of nitric oxide , as well as mimicking the effects of testosterone in rats . It is a weak antioxidant and has antidepressant-like effects in mice . It also has neuroprotective effects in rats.
COA:
| Exterior |
Light yellow to yellow solid |
conform |
| Degree of fineness |
100 mesh |
conform |
| Loss on drying |
<5% |
3.5% |
| Residue on ignition |
<2.5% |
2.1% |
| Icariin |
>10%(HPLC) |
12.9%(HPLC) |
| Distinguish |
(+) |
(+) |
| Heavy Metal |
<5PPM |
conform |
| bacterial |
<1000cfu/g |
40cfu/g |
| Mold |
<100cfu/g |
<10cfu/g |
| E. coli |
Negative |
Negative |
| salmonella |
Negative |
Negative |
| Storage conditions |
Top dry and low temperature sealing |
Top dry and low temperature sealing |
| Conclusion |
conform |
Application:
To effectively treat bone diseases using bone regenerative medicine , there is an urgent need to develop safe cheap drugs that can potently induce bone formation . Here , we demonstrate the osteogenic effect of icariin , the main active compound of Epimedium pubescens . Icariin induced osteogenic differentiation in pre-osteoblastic MC3T3-E1 cells and mouse primary osteoblasts . Icariin upregulated the mRNA expression levels of the osteoblast marker genes runt-related transcription factor 2 (Runx2) and inhibitor of DNA-binding 1 (Id-1) . The osteogenic effect was inhibited by the introduction of Smad6 or dominant-negative Runx2 , as well as Noggin treatment . Furthermore , icariin induced the mRNA expression of bone morphogenetic protein (BMP)-4 . These data suggest that icariin exerts its potent osteogenic effect through induction of Runx2 expression , production of BMP-4 and activation of BMP signaling . The extremely low cost of icariin and its high abundance make it appealing for bone regenerative medicine .
Email:doublewin-eunice@nandrolonesteroid.com
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2. Great quality: High purity and Favorable price. Good quality is the first base of our success. All of our products enjoys high purity. Thus, it can make sure your demand. Welcome order the samples, MOQ just 10 grams.
3. Safe and fast delivery: Lots of different discreet safe packing methods, experience in choosing express, 4~7 days to arrive, successful rate 99%.
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