Prohormones Steroids White Powder Misoprostol for Terminate Pregnancy

99% Prohormones Steroids White Powder Misoprostol for Terminate Pregnancy

Basic info:

Misoprostol
CAS Number: 59122-46-2
Molecular Formula: C22H38O5
Molecular Weight: 382.60
Assay:99%
Density: 1.078 g/cm3
Boiling Point: 497.3 ° C at 760 mmHg
Flash Point: 160.3 ° C
Solubility: Soluble to 100 mM in Ethanol
Appearance: White powder,Water-soluble, viscous liquid
PackAge: Aluminium foil bag packing
Storage: Keep in cool and dry place, away from light
Use: Prostaglandins;Pharmaceuticals;Prostanoid receptor and related

Product info:

Misoprostol is approved for use in the prevention of NSAID-induced gastric ulcers. It acts upon gastric parietal cells, inhibiting the secretion of gastric acid by G-protein coupled receptor-mediated inhibition of adenylate cyclase, which leads to decreased intracellular cyclic AMP levels and decreased proton pump activity at the apical surface of the parietal cell. Because other classes of drugs, especially H2-receptor antagonists and proton pump inhibitors, are more effective for the treatment of acute peptic ulcers, misoprostol is only indicated for use by people who are both taking NSAIDs and are at high risk for NSAID-induced ulcers, including the elderly and people with ulcer complications. Misoprostol is sometimes coprescribed with NSAIDs to prevent their common adverse effect of gastric ulceration (e.g. with diclofenac in Arthrotec).

Misoprostol has other protective actions, but is only clinically effective at doses high enough to reduce gastric acid secretion. For instance, at lower doses, misoprostol may stimulate increased secretion of the protective mucus that lines the gastrointestinal tract and increase mucosal blood flow, thereby increasing mucosal integrity. However, these effects are not pronounced enough to warrant prescription of misoprostol at doses lower than those needed to achieve gastric acid suppression.

However, even in the treatment of NSAID-induced ulcers, omeprazole proved to be at least as effective as misoprostol,but was significantly better tolerated, so misoprostol should not be considered a first-line treatment. Misoprostol-induced diarrhea and the need for multiple daily doses (typically four) are the main issues impairing compliance with therapy.

The most commonly reported adverse effect of taking a misoprostol orally for the prevention of stomach ulcers is diarrhea. In clinical trials, an average 13% of patients reported diarrhea, which was dose-related and usually developed early in the course of therapy (after 13 days) and was usually self-limiting (often resolving within 8 days), but sometimes (in 2% of patients) required discontinuation of misoprostol.

The next most commonly reported adverse effects of taking misoprostol orally for the prevention of gastric ulcers are: abdominal pain, nausea, flatulence, headache, dyspepsia, vomiting, and constipation, but none of these adverse effects occurred significantly more often than when taking placebos. In practice, fever is almost universal when multiple doses are given every 4 to 6 hours.

Misoprostol should not be taken by pregnant women to reduce the risk of NSAID-induced gastric ulcers because it increases uterine tone and contractions in pregnancy, which may cause partial or complete abortions, and because its use in pregnancy has been associated with birth defects.

Product Description:

Misoprostol is a medication used to start labor, induce abortions, prevent and treat stomach ulcers, and treat postpartum bleeding due to insufficient contraction of the uterus. For abortions it is used with mifepristone or methotrexate. It is a synthetic prostaglandin E1 (PGE1).

Common side effects include diarrhea and abdominal pain. It is pregnancy category X meaning that it is known to result in negative fetal outcomes if taken during pregnancy. Uterine rupture may occur.

It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system. Misoprostol was invented and marketed by G.D. Searle & Company under the trade name Cytotec, but other trade names and generic formulations are available.

Biological Activity: Cytoprotective prostaglandin E 1 analog that displays agonist activity at EP receptors. K i values are 120, 250, 67 and 67 nM at cloned mouse EP 1 , EP 2 , EP 3 and EP 4 receptors respectively. Prevents NSAID-induced gastric ulceration. Use for gastric and duodenal ulcers, hemorrhagic gastritis, acute gastric mucosal lesions and other diseases.

The first chemical synthesis of prostaglandin E1 class anti-ulcer drug, a strong inhibition of gastric acid secretion and prevent ulcer formation, can inhibit gastric acid secretion and gastric acid include basic due histamine pentagastrin, food or coffee stimulation gastric acid secretion, but also to reduce gastric acid secretion at night. It is the first clinical application of anti-ulcer drugs. The extension of ulcer recurrence than violate receptor antagonist, but the effect is less than relieve peptic ulcer pain receptor antagonist island. For gastric and duodenal ulcers, especially for cases of low levels of prostaglandins.

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