Description:
Yohimbine Hydrochloride
Alias: Corynine;Aphrodine
CAS No: 65-19-0
Einecs No: 200-600-4
MF: C21H27ClN2O3
MW: 390.91
Purity: 98%
Appearance:White crystalline powder, taste slightly bitter.Soluble in chloroform, soluble in methanol, ethanol, slightly soluble in water.
Description:
Yohimbine readily penetrates the (CNS) and produces a complex pattern of responses in lower doses than those required to produce peripheral alpha-adrenergic blockade. These include, anti-diuresis, a general picture of central excitation including elevation of blood pressure and heart rate, increased motor activity, nervousness, irritability and tremor. Sweating, nausea and vomiting are common after parenteral administration of the drug. Also, dizziness, headache skin flushing reported when used orally.
Generally, this drug is not proposed for use in females and certainly must not be used during pregnancy. Neither is this drug proposed for use in pediatric, geriatric or cardio-renal patients with gastric or duodenal ulcer history. Nor should it be used in conjunction with mood- modifying drugs such as antidepressants, or in psychiatric patients in general.
Renal diseases and patient's sensitive to the drug. In view of the limited and inadequate information at hand, no precise tabulation can be offered of additional contraindications.
It is important that your doctor check your progress at regular visits to make sure that this medicine is working properly.
Applications:
Increase muscular tension or urinary function no damage sex; Accelerate human body energy metabolism, increase energy supply.It is sold as prescription medicine in pure form for the treatment of sexual dysfunction. Yohimbine was explored as a remedy for type 2 diabetes in animal and human models carrying polymorphisms of the α2A-adrenergic receptor gene.
Yohimbine has been shown in human studies to be effective in the treatment of male impotence. Yohimbine has been shown to be effective in the treatment of orgasmic dysfunction in men. Yohimbine has also been used to treat hypoactive sexual desire disorder (reduced libido) in women.
Yohimbine has been used to facilitate recall of traumatic memories in the treatment of post traumatic stress disorder (PTSD). Use of yohimbine outside therapeutic settings may not be appropriate for persons suffering from PTSD. In pharmacology, yohimbine is used as a probe for α2-adrenoceptor. In veterinary medicine, yohimbine is used to reverse anesthesia from the drug xylazine in small and large animals.
Attribute & Effect :
Yohimbine has been shown in human studies to be effective in the treatment of male impotence. Yohimbine has been shown to be effective in the treatment of orgasmic dysfunction in men. Yohimbine has also been used to treat hypoactive sexual desire disorder (reduced libido) in women. Increase muscular tension or urinary function no damage sex; Accelerate human body energy metabolism, increase energy supply.
Yohimbine has been used to facilitate recall of traumatic memories in the treatment of post traumatic stress disorder (PTSD). Use of yohimbine outside therapeutic settings may not be appropriate for persons suffering from PTSD. In pharmacology, yohimbine is used as a probe for α 2-adrenoceptor. In veterinary medicine, yohimbine is used to reverse anesthesia from the drug xylazine in small and large animals.
Increase muscular tension or urinary function no damage sex; Accelerate human body energy metabolism, increase energy supply.
Yohimbine has been shown in human studies to be effective in the treatment of male impotence. Yohimbine has been shown to be effective in the treatment of orgasmic dysfunction in men. Yohimbine has also been used to treat hypoactive sexual desire disorder (reduced libido) in women.
Yohimbine has been used to facilitate recall of traumatic memories in the treatment of post traumatic stress disorder (PTSD). Use of yohimbine outside therapeutic settings may not be appropriate for persons suffering from PTSD. In pharmacology, yohimbine is used as a probe for α 2-adrenoceptor. In veterinary medicine, yohimbine is used to reverse anesthesia from the drug xylazine in small and large animals
Indications and Uses
Yohimbine hydrochloride is indicated as a sympathicolytic and mydriatic. It may have activity as an aphrodisiac.
Impotence (not able to have erections):
The way yohimbine works is not known for sure. It is thought, however, to work by increasing the body's production of certain chemicals that help produce erections. It does not work in all men who are impotent.
New research that shows it could be an herb with very effective antioxidant potential. Research shows it is a vasodilator, which means that it increases blood flow to the extremities and appendages.
Safety Concerns:
Patients sensitive to rauwolfia alkaloids such as deserpidine, rauwolfia serpentina, or reserpine may also be sensitive to yohimbine.
Yohimbine readily penetrates the (CNS) and produces a complex pattern of responses in lower doses than those required to produce peripheral alpha-adrenergic blockade. These include, anti-diuresis, a general picture of central excitation including elevation of blood pressure and heart rate, increased motor activity, nervousness, irritability and tremor. Sweating, nausea and vomiting are common after parenteral administration of the drug. Also, dizziness, headache skin flushing reported when used orally.
Generally, this drug is not proposed for use in females and certainly must not be used during pregnancy. Neither is this drug proposed for use in pediatric, geriatric or cardio-renal patients with gastric or duodenal ulcer history. Nor should it be used in conjunction with mood- modifying drugs such as antidepressants, or in psychiatric patients in general.
Renal diseases and patient's sensitive to the drug. In view of the limited and inadequate information at hand, no precise tabulation can be offered of additional contraindications.
It is important that your doctor check your progress at regular visits to make sure that this medicine is working properly.
Use yohimbine exactly as directed by your doctor. Do not use more of it and do not use it more often than ordered. If too much is used, the risk of side effects such as fast heartbeat and high blood pressure is increased.
Dosage Information:
The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
Specifications:
| ANALYSIS |
SPECIFICATION |
RESULTS |
| Appearance |
White fine powder |
Complies |
| Odor |
Characteristic |
Complies |
| Assay (HPLC) On dry basis |
Yohimbine HCL≥98.0% |
99. 3% |
| Sieve analysis |
NLT 100% pass 80 mesh |
Complies |
| Melting point |
285-290°C |
288.2ºC |
| Boiling point |
542.979°C at 760 mmHg |
Complies |
| Flash point |
282.184°C |
Complies |
| Vapour Pressur |
0mmHg at 25°C |
Complies |
| Specific Rotation |
+100º to +105º |
+103.80º |
| Solubility |
Slightly soluble in Water/Alcohol |
Complies |
| Loss on Drying |
≤1% |
0.7% |
| Residue on Ignition |
≤1% |
0.87% |
| Heavy Metal |
<15ppm |
<10ppm |
| As |
<2.0ppm |
<1ppm |
| Pb |
<1.0ppm |
<0.4ppm |
| Cd |
<1.0ppm |
0ppm |
| Hg |
<0.1ppm |
0ppm |
| Residual Solvents |
Eur.Pharm. |
Complies |
| Microbiology |
|
|
| Total Plate Count |
<1000cfu/g |
Complies |
| Yeast & Moulds |
<100cfu/g |
Complies |
| E.Coli |
Negative |
Complies |
| Salmonella |
Negative |
Complies |
| S.aureus |
Negative |
Complies |
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